CCT367766
Modify Date: 2024-01-16 13:30:32
CCT367766 structure
|
Common Name | CCT367766 | ||
|---|---|---|---|---|
| CAS Number | 2229856-58-8 | Molecular Weight | 946.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H48ClN7O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCT367766CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells. |
| Name | CCT-367766 |
|---|
| Description | CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells. |
|---|---|
| Related Catalog | |
| Target |
CRBN-DDB1:490 nM (IC50) |
| In Vitro | CCT367766 (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells[1]. CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells[1]. Western Blot Analysis[1] Cell Line: SK-OV-3 human ovarian cancer cells Concentration: 50, 150, 250, 500 and 1500 nM Incubation Time: 2 hours, 4 hours, 24 hours Result: Decreased pirin protein expression. Western Blot Analysis[1] Cell Line: SK-OV-3 human ovarian cancer cells Concentration: 0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 nM Incubation Time: 2 hours Result: Completely degraded pirin just at 50 nM treatment. |
| References |
| Molecular Formula | C49H48ClN7O11 |
|---|---|
| Molecular Weight | 946.41 |
| Storage condition | 2-8°C |