ADH-6

Modify Date: 2025-08-27 00:05:30

ADH-6 Structure
ADH-6 structure
 Common Name ADH-6
CAS Number 2227429-65-2 Molecular Weight 640.64
Density N/A Boiling Point N/A
Molecular Formula C29H36N8O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ADH-6


ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].

 Names

Name ADH-6

 ADH-6 Biological Activity

Description ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
Related Catalog
References

[1]. Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.

 Chemical & Physical Properties

Molecular Formula C29H36N8O9
Molecular Weight 640.64
InChIKey KDVRSKDEDDWURT-UHFFFAOYSA-N
SMILES CCCCOc1nc(C(=O)Nc2ccc(C(=O)Nc3ccc(C(=O)OC)nc3OCCCN)nc2OCCCN)ccc1[N+](=O)[O-]
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Chemsrc provides ADH-6(CAS#:2227429-65-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ADH-6 are included as well.>> amp version: ADH-6

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