SZL P1-41
Modify Date: 2024-01-22 22:06:24
SZL P1-41 structure
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Common Name | SZL P1-41 | ||
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| CAS Number | 222716-34-9 | Molecular Weight | 420.524 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 610.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H24N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 322.7±34.3 °C | |
Use of SZL P1-41SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.target: Skp2In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. |
| Name | SZL-P1-41 |
|---|---|
| Synonym | More Synonyms |
| Description | SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.target: Skp2In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis.In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.0±65.0 °C at 760 mmHg |
| Molecular Formula | C24H24N2O3S |
| Molecular Weight | 420.524 |
| Flash Point | 322.7±34.3 °C |
| Exact Mass | 420.150757 |
| LogP | 4.85 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.687 |
| Storage condition | 2-8℃ |
| 3-(1,3-Benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)- |
| 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one |
| SZL-P1-41 |