Zotarolimus

Modify Date: 2024-01-02 17:46:43

Zotarolimus Structure
Zotarolimus structure
Common Name Zotarolimus
CAS Number 221877-54-9 Molecular Weight 966.210
Density 1.3±0.1 g/cm3 Boiling Point 1016.2±75.0 °C at 760 mmHg
Molecular Formula C52H79N5O12 Melting Point 100-105°C
MSDS N/A Flash Point 568.4±37.1 °C

 Use of Zotarolimus


Zotarolimus is a tetrazole-containing Rapamycin analog which is used as animmunomodulator, and is useful in the treatment of restenosis, immune, and autoimmune diseases.

 Names

Name Zotarolimus
Synonym More Synonyms

 Zotarolimus Biological Activity

Description Zotarolimus is a tetrazole-containing Rapamycin analog which is used as animmunomodulator, and is useful in the treatment of restenosis, immune, and autoimmune diseases.
Related Catalog
References

[1]. Wagner R et al. Rapamycin analogs with reduced systemic exposure. et al. Bioorg Med Chem Lett. 2005 Dec 1, 15(23), 5340-3.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1016.2±75.0 °C at 760 mmHg
Melting Point 100-105°C
Molecular Formula C52H79N5O12
Molecular Weight 966.210
Flash Point 568.4±37.1 °C
Exact Mass 965.572510
PSA 218.80000
LogP 3.55
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.586
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Safety Information

HS Code 29349990

 Synonyms

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-19,30-dimethoxy-12-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-2-propanyl}-15,17,21,23,29,35-hexamethyl-11, ;36-dioxa-4-azatricyclo[30.3.1.0]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-10,21-dimethoxy-3-[(1R)-2-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]-1-methylethyl]-6,8,12,14,20,26-hexamethyl-, (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-3-{(2R)-1-[(1S,3R,4S)-3-methoxy-4-(1H-tetrazol-1-yl)cyclohexyl]propan-2-yl}-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Zotarolimus
ABT-578
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