(17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol

Modify Date: 2024-01-08 12:48:01

(17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol structure	Common Name	(17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol
	CAS Number	221093-33-0	Molecular Weight	293.41
	Density	1.2±0.1 g/cm3	Boiling Point	481.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₉D₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	227.6±23.3 °C

Use of (17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol

2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].

Name	2-hydroxy-17beta-estradiol-1,4,16,16,17-d5
Synonym	More Synonyms

Description	2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [3]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [4]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53.

Density	1.2±0.1 g/cm3
Boiling Point	481.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₉D₅O₃
Molecular Weight	293.41
Flash Point	227.6±23.3 °C
Exact Mass	289.178833
PSA	60.69000
LogP	3.53
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.622

(17β)-(17-H)Estra-1(10),2,4-triene-2,3,17-triol

2-Hydroxy-17b-estradiol-1,4,16,16,17-d5

Estra-1(10),2,4-triene-17-d-2,3,17-triol, (17β)-

2-Hydroxy-17-estradiol-d5

2-Hydroxyestradiol-1,4,16,16,17-d5

(17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol

Use of (17β)-(17-2H)Estra-1(10),2,4-triene-2,3,17-triol

Names

Biological Activity

Chemical & Physical Properties

Synonyms