MMPSI

Modify Date: 2024-01-09 19:48:36

MMPSI Structure
MMPSI structure
Common Name MMPSI
CAS Number 220509-74-0 Molecular Weight 324.35
Density N/A Boiling Point N/A
Molecular Formula C14H16N2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MMPSI


MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].

 Names

Name (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Synonym More Synonyms

 MMPSI Biological Activity

Description MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection[1].
Related Catalog
Target

human Caspase-3:1.7 μM (IC50)

References

[1]. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.

 Chemical & Physical Properties

Molecular Formula C14H16N2O5S
Molecular Weight 324.35
Exact Mass 324.07800
PSA 101.16000
LogP 1.77760

 Synonyms

(S)-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin
(S)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
5-((S)-2-Methoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
(S)-5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione
5-(S)-(2-methoxymethyl)pyrrolidinylsulfonyl isatin
(S)-(+)-5-[2-methoxymethylpyrrolidin-1-ylsulfonyl]isatin
(S)-5-[(2-methoxymethylpyrrolidin-1-yl)sulfonyl]isatin
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