Thioquinapiperifil

Modify Date: 2025-10-18 23:51:40

Thioquinapiperifil structure	Common Name	Thioquinapiperifil
	CAS Number	220060-39-9	Molecular Weight	448.58400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₈N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thioquinapiperifil

Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].

Name	3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione

Description	Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Metabolic Disease
Target	PDE5:0.074 nM (IC50) PDE1:380 nM (IC50) PDE2:670 nM (IC50) PDE3:38 nM (IC50) PDE4:800 nM (IC50)
In Vitro	Thioquinapiperifil can be found in dietary supplements[1]. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation[2]. Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/108 cells[2].
References	[1]. Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. [2]. R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24.

Molecular Formula	C₂₄H₂₈N₆OS
Molecular Weight	448.58400
Exact Mass	448.20500
PSA	121.13000
LogP	3.59580
InChIKey	NMKUPEWPVORTPC-UHFFFAOYSA-N
SMILES	CCn1c(=S)[nH]c2cc3c(NCc4ccccc4N4CCC(CO)CC4)ncnc3cc21

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: KF31327 free base
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Thioquinapiperifil
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.