MP A08

Modify Date: 2024-01-13 14:04:29

MP A08 structure	Common Name	MP A08
	CAS Number	219832-49-2	Molecular Weight	519.635
	Density	1.3±0.1 g/cm3	Boiling Point	717.1±70.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₅N₃O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	387.5±35.7 °C

Use of MP A08

MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SphK1 and SphK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.In vitro:MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]In vivo: MP-A08 suppresses the growth of human lung tumor xenografts in mice.

Name	MP-A08
Synonym	More Synonyms

Description	MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SphK1 and SphK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.In vitro:MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]In vivo: MP-A08 suppresses the growth of human lung tumor xenografts in mice.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> SPHK Research Areas >> Cancer
References	[1]. Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6(9):7065-83. [2]. Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23(3):248-65.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> SPHK

Research Areas >> Cancer

References

[1]. Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6(9):7065-83.

[2]. Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23(3):248-65.

Density	1.3±0.1 g/cm3
Boiling Point	717.1±70.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₅N₃O₄S₂
Molecular Weight	519.635
Flash Point	387.5±35.7 °C
Exact Mass	519.128662
LogP	5.31
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.634
Storage condition	2-8℃

4-Methyl-N-{2-[(E)-(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide

Benzenesulfonamide, 4-methyl-N-[2-[(E)-[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-

DC Chemicals Limited
China
Product Name: MP-A08
Price: $280.0/5mg $400.0/10mg $1200.0/50mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $480/10mM*1mLinDMSO

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MP A08

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