PMX 53
Modify Date: 2024-04-14 17:48:39
PMX 53 structure
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Common Name | PMX 53 | ||
|---|---|---|---|---|
| CAS Number | 219639-75-5 | Molecular Weight | 896.089 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C47H65N11O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PMX 53PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells; PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2; inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats. |
| Name | Nα-Acetyl-N-[3-(cyclohexylmethyl)-9-{3-[(diaminomethylene)amino]propyl}-6-(1H-indol-3-ylmethyl)-1,4,7,10,16-pentaoxoicosahydropyrrolo[1,2-a][1,4,7,10,13]pentaazacyclooctadecin-15-yl]phenylalaninamidato |
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| Synonym | More Synonyms |
| Description | PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells; PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2; inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats. |
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| References | References 1. Ting E, et al. Br J Pharmacol. 2008 Mar;153(5):1043-53. 2. Subramanian H, et al. Mol Pharmacol. 2011 Jun;79(6):1005-13. 3. Liu H, et al. Nat Struct Mol Biol. 2018 Jun;25(6):472-481. 4. Finch AM, et al. J Med Chem. 1999 Jun 3;42(11):1965-74. View Related Products by Target Complement System |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C47H65N11O7 |
| Molecular Weight | 896.089 |
| Exact Mass | 895.506836 |
| LogP | 0.81 |
| Index of Refraction | 1.684 |
| InChIKey | YOKBGCTZYPOSQM-UNHORJANSA-N |
| SMILES | CC(=O)NC(Cc1ccccc1)C(=O)NC1CCCNC(=O)C(CCCN=C(N)N)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C1=O |
| Storage condition | -20°C |
| Benzenepropanamide, α-(acetylamino)-N-[3-(cyclohexylmethyl)-9-[3-[(diaminomethylene)amino]propyl]eicosahydro-6-(1H-indol-3-ylmethyl)-1,4,7,10,16-pentaoxopyrrolo[1,2-a][1,4,7,10,13]pentaazacyclooct adecin-15-yl]- |
| Nα-Acetyl-N-[3-(cyclohexylmethyl)-9-{3-[(diaminomethylene)amino]propyl}-6-(1H-indol-3-ylmethyl)-1,4,7,10,16-pentaoxoicosahydropyrrolo[1,2-a][1,4,7,10,13]pentaazacyclooctadecin-15-yl]phenylalaninam idato |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: PMX-53
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
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- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: PMX53
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
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- DC Chemicals Limited
- China
- Product Name: PMX-53
- Price: $1900.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: PMX 53
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Vinnie
- Email: Jamie@api-made.com
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