SCH00013
Modify Date: 2025-12-06 22:56:09
SCH00013 structure
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Common Name | SCH00013 | ||
|---|---|---|---|---|
| CAS Number | 217963-18-3 | Molecular Weight | 324.377 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H20N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SCH00013SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. [1]In vivo: The positive inotropic effects of 10?4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. [1] CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. [2] SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate. [3] |
| Name | SCH00013 |
|---|---|
| Synonym | More Synonyms |
| Description | SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.In vitro: SCH00013 at 10-4 M increased the systolic cell shortening by 52% above the base-line value in association with an insignificant increase in the systolic fluorescence ratio by 15% above the control. [1]In vivo: The positive inotropic effects of 10?4 M SCH00013 on the dog and rabbit were 38% and 29% of the maximal response to isoproterenol. [1] CH00013 elicited a positive inotropic effect at more than 0.3 and 1 mg/kg, i.v. in normal and heart failure dogs. [2] SCH00013 elicits a positive inotropic effect mainly through an increase in myofilament Ca2+ sensitivity without increasing the heart rate. [3] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H20N4O2 |
| Molecular Weight | 324.377 |
| Exact Mass | 324.158630 |
| LogP | 0.15 |
| Index of Refraction | 1.659 |
| InChIKey | BPEKLIDKLJZYOX-UHFFFAOYSA-N |
| SMILES | N#Cc1ccc(C(O)CN2CC=C(C3=NNC(=O)CC3)CC2)cc1 |
| Storage condition | 2-8℃ |
| Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]- |
| 4-{1-Hydroxy-2-[4-(6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-3,6-dihydro-1(2H)-pyridinyl]ethyl}benzonitrile |