L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

Modify Date: 2025-10-04 19:38:42

L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- structure	Common Name	L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-
	CAS Number	2179-16-0	Molecular Weight	455.42400
	Density	1.64g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁N₇O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

Ninopterin (9-Me-PGA; 9-Methyl PGA) is a folic acid analog[1].

Name	L-Glutamic acid, 9-methylpteroyl
Synonym	More Synonyms

Description	Ninopterin (9-Me-PGA; 9-Methyl PGA) is a folic acid analog[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. K P Chepenik, Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on respiratory control ratios, phosphorylative capacity, and cytochrome oxidase activities of mitochondria from rat embryos. Teratology (Report missing IFs). 1972 Apr;5(2):191-8.

Density	1.64g/cm3
Molecular Formula	C₂₀H₂₁N₇O₆
Molecular Weight	455.42400
Exact Mass	455.15500
PSA	213.54000
LogP	1.97360
Index of Refraction	1.746

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0602000

CHEMICAL NAME :: Glutamic acid, N-(p-((1-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino) benzoyl)- L-

CAS REGISTRY NUMBER :: 2179-16-0

BEILSTEIN REFERENCE NO. :: 0069787

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H21-N7-O6

MOLECULAR WEIGHT :: 455.48

WISWESSER LINE NOTATION :: T6MTJ BZ DQ F2MR DVMYVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 1,375,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 405 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970- Volume(issue)/page/year: 41,52,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 11-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED Volume(issue)/page/year: 41,289,1977

6-Hydroxy-2,4,5...

CAS#:1004-75-7

N-(4-aminobenzo...

CAS#:4271-30-1

L-Glutamic acid...

CAS#:2179-16-0

Literature: Hultquist et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 619,621.

Precursor 2
CAS#:1004-75-7 6-Hydroxy-2,4,5... CAS#:4271-30-1 N-(4-aminobenzo...
DownStream 0

Bremfol

ninopterin

9-Methyl-PGA

Folic acid,9-methyl

9-Methyl pteroylglutamic acid

9-Me-pga

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L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

Use of L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.