RUNX-IN-1

Modify Date: 2025-08-24 20:22:55

RUNX-IN-1 Structure
RUNX-IN-1 structure
Common Name RUNX-IN-1
CAS Number 2177285-35-5 Molecular Weight 1524.52
Density N/A Boiling Point N/A
Molecular Formula C71H88Cl2N24O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RUNX-IN-1


RUNX-IN-1 (Compound Conjugate 1) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-1 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-1 inhibits tumor growth in PANC-1 xenograft mice[1].

 Names

Name RUNX-IN-1

 RUNX-IN-1 Biological Activity

Description RUNX-IN-1 (Compound Conjugate 1) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-1 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-1 inhibits tumor growth in PANC-1 xenograft mice[1].
Related Catalog
Target

RUNX[1]

References

[1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.  

 Chemical & Physical Properties

Molecular Formula C71H88Cl2N24O11
Molecular Weight 1524.52
InChIKey KEMUNUGWVPYFER-UHFFFAOYSA-N
SMILES CN(C)CCCNC(=O)c1cc(NC(=O)c2cc(NC(=O)c3cc(NC(=O)c4cc(NC(=O)CCCNC(=O)c5nc(NC(=O)c6nc(NC(=O)c7cc(NC(=O)c8nc(NC(=O)CCNC(=O)CCCc9ccc(N(CCCl)CCCl)cc9)cn8C)cn7C)cn6C)cn5C)cn4C)cn3C)cn2C)cn1C
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