BCX 1470 (methanesulfonate)

Modify Date: 2025-08-26 18:41:04

BCX 1470 (methanesulfonate) structure	Common Name	BCX 1470 (methanesulfonate)
	CAS Number	217099-44-0	Molecular Weight	398.47700
	Density	N/A	Boiling Point	509.9ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₄N₂O₅S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	262.2ºC

Use of BCX 1470 (methanesulfonate)

BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

Name	2-Thiophenecarboxylic acid 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester methanesulfonate (1:1)
Synonym	More Synonyms

Description	BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Inflammation/Immunology
References	[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 [2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> Complement System

Research Areas >> Inflammation/Immunology

References

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468

[2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

Boiling Point	509.9ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄N₂O₅S₃
Molecular Weight	398.47700
Flash Point	262.2ºC
Exact Mass	398.00600
PSA	195.40000
LogP	4.85090
Storage condition	2-8℃

BCX 1470 methanesulfonate

BCX 1470 (methanesulfonate)

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China
Product Name: BCX 1470(METHANESULFONATE)
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Price: $462/10mM*1mLinDMSO

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BCX 1470 (methanesulfonate)

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