Pyridine,3-(3,3-dimethyl-1-triazen-1-yl)-, 1-oxide

MOLECULAR FORMULA :

C7-H10-N4-O

MOLECULAR WEIGHT :

166.21

WISWESSER LINE NOTATION :

T6NJ AO CNUNN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

230 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

490 mg/kg/38W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors

TYPE OF TEST :

TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

540 mg/kg/36W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TYPE OF TEST :

Heritable translocation test

MUTATION DATA

TYPE OF TEST :

Host-mediated assay

TEST SYSTEM :

Rodent - mouse Yeast - Saccharomyces cerevisiae

DOSE/DURATION :

400 umol/kg

REFERENCE :

AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 3,99,1973