Thalidomide-4-NH-PEG2-COO(t-Bu)
Modify Date: 2024-01-12 19:58:07
Thalidomide-4-NH-PEG2-COO(t-Bu) structure
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Common Name | Thalidomide-4-NH-PEG2-COO(t-Bu) | ||
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| CAS Number | 2140807-16-3 | Molecular Weight | 489.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H31N3O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide-4-NH-PEG2-COO(t-Bu)Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
| Name | Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-, 1,1-dimethylethyl ester |
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| Synonym | More Synonyms |
| Description | Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
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| Related Catalog |
| Molecular Formula | C24H31N3O8 |
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| Molecular Weight | 489.52 |
| propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl]amino]e |