BAY-677

Modify Date: 2025-08-26 15:13:49

BAY-677 structure	Common Name	BAY-677
	CAS Number	2117404-84-7	Molecular Weight	400.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₅F₃N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BAY-677

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM[1]. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC)[2].

Name	BAY-677

Description	BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM[1]. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC)[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.. [2]. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73..

[2]. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81.

Molecular Formula	C₂₀H₁₅F₃N₄O₂
Molecular Weight	400.35
Storage condition	2-8℃

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China
Product Name: BAY-677?
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DC Chemicals Limited
China
Product Name: Bay-677
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥880/10 mM * 1 mL in DMSO

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BAY-677

Use of BAY-677

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BAY-677 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.