(S,S,S)-AHPC hydrochloride

Modify Date: 2025-08-26 18:20:15

(S,S,S)-AHPC hydrochloride Structure
(S,S,S)-AHPC hydrochloride structure
Common Name (S,S,S)-AHPC hydrochloride
CAS Number 2115897-23-7 Molecular Weight 467.02
Density N/A Boiling Point N/A
Molecular Formula C22H31ClN4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S,S,S)-AHPC hydrochloride


(S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].

 Names

Name (S,S,S)-AHPC hydrochloride

 (S,S,S)-AHPC hydrochloride Biological Activity

Description (S,S,S)-AHPC hydrochloride is a von Hippel-Lindau (VHL) amino building block. (S,S,S)-AHPC is a ligand used as a negative control for (S,R,S)-AHPC. (S,R,S)-AHPC is the VH032-based VHL ligand used in the recruitment of the VHL protein[1].
Related Catalog
Target

VHL

In Vitro The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
References

[1]. Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J Med Chem. 2018 Jan 25;61(2):583-598.

 Chemical & Physical Properties

Molecular Formula C22H31ClN4O3S
Molecular Weight 467.02
Storage condition -20°C
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