RN 9893 hydrochloride

Modify Date: 2025-08-25 16:16:53

RN 9893 hydrochloride Structure
RN 9893 hydrochloride structure
Common Name RN 9893 hydrochloride
CAS Number 2109450-40-8 Molecular Weight 536.95
Density N/A Boiling Point N/A
Molecular Formula C21H23F3N4O5S.HCl Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RN 9893 hydrochloride


A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.

 Names

Name RN-9893 hydrochloride

 RN 9893 hydrochloride Biological Activity

Description A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.
References References 1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5. View Related Products by Target TRP Channel

 Chemical & Physical Properties

Molecular Formula C21H23F3N4O5S.HCl
Molecular Weight 536.95
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