Cowanin
Modify Date: 2024-09-29 19:16:47
Cowanin structure
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Common Name | Cowanin | ||
|---|---|---|---|---|
| CAS Number | 21044-85-9 | Molecular Weight | 478.585 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H34O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CowaninCowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM; shows high efficient cytotoxicity against human leukemic cancer cells HPB-ALL (IC50=7.5 uM) than that of DAPT, decreases the protein levels of HES1 and HES5 in assay cells; accelerates nicastrin degradation, which is one of the components of the γ-secretase complex; also inhibits cell proliferation and induces apoptosis of LoVo cells via the MAPK and Akt signaling pathways. |
| Name | Cowanin |
|---|
| Description | Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM; shows high efficient cytotoxicity against human leukemic cancer cells HPB-ALL (IC50=7.5 uM) than that of DAPT, decreases the protein levels of HES1 and HES5 in assay cells; accelerates nicastrin degradation, which is one of the components of the γ-secretase complex; also inhibits cell proliferation and induces apoptosis of LoVo cells via the MAPK and Akt signaling pathways. |
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| References | References 1. Arai MA, et al. Sci Rep. 2018 Mar 29;8(1):5376. 2. Chowchaikong N, et al. Int J Oncol. 2018 Apr 3. doi: 10.3892/ijo.2018.4353. View Related Products by Target Notch |
| Molecular Formula | C29H34O6 |
|---|---|
| Molecular Weight | 478.585 |