LY900009
Modify Date: 2025-08-25 18:11:22
LY900009 structure
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Common Name | LY900009 | ||
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| CAS Number | 209984-68-9 | Molecular Weight | 409.48 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 781.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C23H27N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 426.5±32.9 °C | |
Use of LY900009LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI). LY900009 inhibited Notch signalling in tumor cell lines and endothelial cells (IC50 range: 0.005-20 nM). LY900009 can be used for advanced cancer research[1]. |
| Name | (2S)-2-Hydroxy-3-methyl-N-[(2S)-1-{[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]amino}-1-oxo-2-propanyl]butanamide |
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| Synonym | More Synonyms |
| Description | LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI). LY900009 inhibited Notch signalling in tumor cell lines and endothelial cells (IC50 range: 0.005-20 nM). LY900009 can be used for advanced cancer research[1]. |
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| Related Catalog | |
| In Vivo | 在大鼠模型中，LY900009 (口服灌胃；3 mg/kg；单剂量) 通过形成渗漏脉管系统抑制血管生成，并在 Notch 依赖性肿瘤模型中导致肿瘤消退[1]。 |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 781.5±60.0 °C at 760 mmHg |
| Molecular Formula | C23H27N3O4 |
| Molecular Weight | 409.48 |
| Flash Point | 426.5±32.9 °C |
| Exact Mass | 409.200165 |
| LogP | 3.97 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.622 |
| InChIKey | JURYTIUJMYPBNN-GKCIPKSASA-N |
| SMILES | CC(NC(=O)C(O)C(C)C)C(=O)NC1C(=O)N(C)c2ccccc2-c2ccccc21 |
| Storage condition | -20℃ |
| Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-2-hydroxy-3-methyl-, (2S)- |
| (2S)-2-Hydroxy-3-methyl-N-[(2S)-1-{[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]amino}-1-oxo-2-propanyl]butanamide |
| LY900009 |