6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
Modify Date: 2024-04-06 18:20:45
![6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride Structure](https://www.chemsrc.com/caspic/402/2095432-28-1.png)
6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride structure
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Common Name | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride | ||
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| CAS Number | 2095432-28-1 | Molecular Weight | 314.770 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H15ClN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochlorideCPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. |
| Name | CPI-455 Hydrochloride |
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| Synonym | More Synonyms |
| Description | CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. |
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| Related Catalog | |
| Target |
KDM5 |
| In Vitro | CPI-455 hydrochloride 介导 KDM5 抑制，提高 H3K4 三甲基化 (H3K4me3) 的总体水平，并减少使用标准化疗或靶向药物治疗的多种癌细胞系模型中的 DTP 数量[1]。 CPI-455 盐酸盐，对目标 KDM5 蛋白具有高亲和力。在 24 小时内，在暴露于两种活性化合物 CPI-455 和 CPI-766 中的任何一种后，观察到 H3K4me3 以剂量依赖性方式增加。 KDM5 Inhibitor CPI0455 在 3 种管腔乳腺癌细胞系 MCF-7、T-47 和 EFM-19 中的 IC50 计算值分别为 35.4、26.19 和 16.13 μM[2]。 |
| In Vivo | 在小鼠体内双重阻断 B7-H4 和 KDM5B（CPI-455 hydrochloride，50/70 mg/kg，腹腔注射，每日）可引发保护性免疫[2]。 |
| References |
[2]. Benjamin R. Leadem. NOVEL HISTONE DEMETHYLASE INHIBITORS SYNERGISTICALLY |
| Molecular Formula | C16H15ClN4O |
|---|---|
| Molecular Weight | 314.770 |
| Exact Mass | 314.093445 |
| Storage condition | Inert atmosphere,2-8°C |
| 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride (1:1) |
| Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-, hydrochloride (1:1) |