(R)-Posenacaftor sodium
Modify Date: 2025-08-26 10:32:48
(R)-Posenacaftor sodium structure
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Common Name | (R)-Posenacaftor sodium | ||
|---|---|---|---|---|
| CAS Number | 2095064-09-6 | Molecular Weight | 467.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H26NNaO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (R)-Posenacaftor sodium(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1]. |
| Name | (R)-Posenacaftor sodium |
|---|
| Description | (R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1]. |
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| Related Catalog | |
| Target |
IC50: CFTR[1] |
| In Vitro | Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1]. CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1]. Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2]. |
| References |
| Molecular Formula | C27H26NNaO5 |
|---|---|
| Molecular Weight | 467.49 |