OTS193320
Modify Date: 2024-04-09 22:09:40
OTS193320 structure
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Common Name | OTS193320 | ||
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| CAS Number | 2093401-33-1 | Molecular Weight | 536.029 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30ClN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OTS193320OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM. |
| Name | OTS193320 |
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| Description | OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM. |
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| References | References 1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C28H30ClN5O4 |
|---|---|
| Molecular Weight | 536.029 |