Fosmanogepix

Modify Date: 2024-01-04 18:09:56

Fosmanogepix Structure
Fosmanogepix structure
Common Name Fosmanogepix
CAS Number 2091769-17-2 Molecular Weight 468.40
Density N/A Boiling Point N/A
Molecular Formula C22H21N4O6P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fosmanogepix


Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections[1][2].

 Names

Name Fosmanogepix

 Fosmanogepix Biological Activity

Description Fosmanogepix (APX001) is a first-in-class and orally available broad-spectrum antifungal agent, which targets the highly conserved Gwt1 fungal enzyme. Fosmanogepix (APX001) is an N-phosphonooxymethyl prodrug which is rapidly and completely metabolized by systemic alkaline phosphatases to the active moiety, APX001A. Fosmanogepix (APX001) can be used in development for the treatment of invasive fungal infections[1][2].
Related Catalog
Target

Gwt1[1]

References

[1]. Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18.

[2]. Gebremariam T, et al. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01713-18.

 Chemical & Physical Properties

Molecular Formula C22H21N4O6P
Molecular Weight 468.40
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