SRPKIN-1
Modify Date: 2025-09-30 15:12:19
SRPKIN-1 structure
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Common Name | SRPKIN-1 | ||
|---|---|---|---|---|
| CAS Number | 2089226-94-6 | Molecular Weight | 472.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H21FN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRPKIN-1SRPK-IN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. |
| Name | SRPK-IN-1 |
|---|
| Description | SRPK-IN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 35.6 nM (SRPK1), 98 nM (SRPK2)[1] |
| In Vitro | SRPK-IN-1 treatment at 200 nM significantly reduces SR protein phosphorylation at the steady state with or without washout[1]. SRPK-IN-1 potently converts VEGF from pro-angiogenic to anti-angiogenic isoform[1]. |
| In Vivo | SRPK-IN-1 blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1]. |
| References |
| Molecular Formula | C27H21FN2O3S |
|---|---|
| Molecular Weight | 472.53 |
| InChIKey | TWKWEBMGDALHPN-UHFFFAOYSA-N |
| SMILES | CCc1cc2c(cc1-c1cccc(S(=O)(=O)F)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O |