TAS0728
Modify Date: 2024-01-14 14:03:16
TAS0728 structure
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Common Name | TAS0728 | ||
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| CAS Number | 2088323-16-2 | Molecular Weight | 504.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H32N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TAS0728TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33, 25, 86 and 36 nM for BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2, respectively. TAS0728 also inhibits the phosphorylation of HER2, HER3, and downstream effectors, shows no obvious effect on EGFR. Antitumor activity[1]. |
| Name | TAS0728 |
|---|
| Description | TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM. TAS0728 shows IC50s of 4.9, 8.5, 31, 65, 33, 25, 86 and 36 nM for BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and human HER2, respectively. TAS0728 also inhibits the phosphorylation of HER2, HER3, and downstream effectors, shows no obvious effect on EGFR. Antitumor activity[1]. |
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| Related Catalog | |
| Target |
HER4:8.5 nM (IC50) HER2:13 nM (IC50) Human HER2:36 nM (IC50) EGFR:65 nM (IC50) BMX:4.9 nM (IC50) BLK:31 nM (IC50) JAK3:33 nM (IC50) SLK:25 nM (IC50) LOK:86 nM (IC50) |
| References |
| Molecular Formula | C26H32N8O3 |
|---|---|
| Molecular Weight | 504.58 |