MBM-17
Modify Date: 2025-09-10 14:57:57
MBM-17 structure
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Common Name | MBM-17 | ||
|---|---|---|---|---|
| CAS Number | 2083621-90-1 | Molecular Weight | 480.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H28N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MBM-17MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. |
| Name | MBM-17 |
|---|
| Description | MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. |
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| Related Catalog | |
| Target |
IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1] |
| In Vitro | MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1]. |
| References |
| Molecular Formula | C28H28N6O2 |
|---|---|
| Molecular Weight | 480.56 |