A1874
Modify Date: 2025-08-25 07:41:27
A1874 structure
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Common Name | A1874 | ||
|---|---|---|---|---|
| CAS Number | 2064292-12-0 | Molecular Weight | 1173.59 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H62Cl3F2N9O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of A1874A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1]. |
| Name | A1874 |
|---|
| Description | A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4 |
| In Vitro | Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) induces a dose-dependent knockdown of BRD4 levels, with near-maximum knockdown by 100 nmol/L and a maximum degradation (Dmax) of BRD4 of 98% of the levels in control (0.1% DMSO-treated) cells[1]. Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) increases p53 levels in the HCT116 cells and showed dose-dependent p53 stabilization[1]. Western Blot Analysis[1] Cell Line: HCT116 cells. Concentration: 0-10 μM. Incubation Time: 24 hours. Result: Induced a dosedependent knockdown of BRD4 levels, with near-maximum knockdown by 100 nM. |
| References |
| Molecular Formula | C58H62Cl3F2N9O7S |
|---|---|
| Molecular Weight | 1173.59 |
| InChIKey | IPNTVOAQOGRLQB-JJMBTQCASA-N |
| SMILES | COc1cc(C(=O)NCCOCCOCCOCCNC(=O)CC2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)ccc1NC(=O)C1NC(CC(C)(C)C)C(C#N)(c2ccc(Cl)cc2F)C1c1cccc(Cl)c1F |
| Storage condition | 2-8℃ |