dTAG-7

Modify Date: 2025-09-10 18:30:48

dTAG-7 Structure
dTAG-7 structure
 Common Name dTAG-7
CAS Number 2064175-32-0 Molecular Weight 1210.32
Density N/A Boiling Point N/A
Molecular Formula C63H79N5O19 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of dTAG-7


FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].

 Names

Name FKBP12 PROTAC dTAG-7

 dTAG-7 Biological Activity

Description FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].
Related Catalog
Target

FKBP12(F36V)

BRD4

Cereblon

References

[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

 Chemical & Physical Properties

Molecular Formula C63H79N5O19
Molecular Weight 1210.32
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Chemsrc provides dTAG-7(CAS#:2064175-32-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of dTAG-7 are included as well.>> amp version: dTAG-7

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