SB273005

Modify Date: 2025-08-25 09:24:20

SB273005 Structure
SB273005 structure
Common Name SB273005
CAS Number 205678-31-5 Molecular Weight 451.44
Density 1.3±0.1 g/cm3 Boiling Point 662.9±55.0 °C at 760 mmHg
Molecular Formula C22H24F3N3O4 Melting Point N/A
MSDS N/A Flash Point 354.7±31.5 °C

 Use of SB273005


SB-273005 is a potent nonpeptide and orally active integrin antagonist with Kis of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively[1].

 Names

Name HG7MY8V9AA
Synonym More Synonyms

 SB273005 Biological Activity

Description SB-273005 is a potent nonpeptide and orally active integrin antagonist with Kis of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively[1].
Related Catalog
References

[1]. Badger AM, et al. Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis. Arthritis Rheum. 2001 Jan;44(1):128-37.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 662.9±55.0 °C at 760 mmHg
Molecular Formula C22H24F3N3O4
Molecular Weight 451.44
Flash Point 354.7±31.5 °C
Exact Mass 451.171906
LogP 3.16
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.563
Storage condition -20℃

 Synonyms

[(4S)-8-{2-[6-(Methylamino)-2-pyridinyl]ethoxy}-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-yl]acetic acid
1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-8-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-, (4S)-
[(4S)-8-{2-[6-(methylamino)pyridin-2-yl]ethoxy}-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-yl]acetic acid
HG7MY8V9AA
SB273005
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