Nemifitide diTFA

Modify Date: 2025-08-27 19:01:16

Nemifitide diTFA structure	Common Name	Nemifitide diTFA
	CAS Number	204992-09-6	Molecular Weight	922.80
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₄₅F₇N₁₀O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nemifitide diTFA

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].

Name	Nemifitide diTFA

Description	Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].
In Vivo	Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2]. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2]. Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2] Dosage: 0.3 mg/kg Administration: IP; daily; for 14 days Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.
References	[1]. Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5. [2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl). 2004 Sep;175(3):303-9. [3]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9(5):517-28.

Molecular Formula	C₃₇H₄₅F₇N₁₀O₁₀
Molecular Weight	922.80
InChIKey	QXCFOJXOLMOPRK-QOXNQHIRSA-N
SMILES	NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(CCCN=C(N)N)NC(=O)C1CC(O)CN1C(=O)C(N)Cc1ccc(F)cc1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nemifitide diTFA
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Nemifitide diTFA
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Nemifitide diTFA
Price: $800.0/100mg $1300.0/250mg $2600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥4570/10 mM * 1 mL in Water

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Nemifitide diTFA

Use of Nemifitide diTFA

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Nemifitide diTFA Biological Activity

Chemical & Physical Properties

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