Mosnodenvir

Modify Date: 2025-08-25 11:26:59

Mosnodenvir structure	Common Name	Mosnodenvir
	CAS Number	2043343-94-6	Molecular Weight	582.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₂ClF₃N₂O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mosnodenvir

Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral agent with a high barrier to resistance, and is safe and well-tolerated. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice[1][2].

Name	Mosnodenvir

Description	Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral agent with a high barrier to resistance, and is safe and well-tolerated. Mosnodenvir blocks the NS3-NS4B interaction within the viral replication complex. Mosnodenvir shows picomolar to low nanomolar in vitro antiviral activity in mice[1][2].
Related Catalog	Research Areas >> Infection
References	[1]. Ackaert O, et al. Safety, tolerability and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a Phase 1, double-blind, randomized, dose-escalation study in healthy volunteers. Clin Infect Dis. 2023 May 10:ciad284. [2]. Goethals O, et al. Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates. Nature. 2023 Mar;615(7953):678-686.

Description

Related Catalog

Research Areas >> Infection

References

[1]. Ackaert O, et al. Safety, tolerability and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a Phase 1, double-blind, randomized, dose-escalation study in healthy volunteers. Clin Infect Dis. 2023 May 10:ciad284.

[2]. Goethals O, et al. Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates. Nature. 2023 Mar;615(7953):678-686.

Molecular Formula	C₂₆H₂₂ClF₃N₂O₆S
Molecular Weight	582.98
InChIKey	QNOPDDHSGQQLCV-DEOSSOPVSA-N
SMILES	COc1cc(NC(C(=O)c2c[nH]c3ccc(OC(F)(F)F)cc23)c2ccc(Cl)cc2OC)cc(S(C)(=O)=O)c1

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Mosnodenvir

Use of Mosnodenvir

Names

Mosnodenvir Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.