WNK463

Modify Date: 2025-08-26 20:38:50

WNK463 Structure
WNK463 structure
Common Name WNK463
CAS Number 2012607-27-9 Molecular Weight 463.456
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H24F3N7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WNK463


WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.

 Names

Name N-(2-Methyl-2-propanyl)-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl}-4-piperidinyl)-1H-imidazole-5-carboxamide
Synonym More Synonyms

 WNK463 Biological Activity

Description WNK463 is an orally bioavailable pan-WNK-kinase inhibitor with IC50s of 5, 1, 6, and 9 nM for WNK1, WNK 2, WNK 3, and WNK 4, respectively.
Related Catalog
References

[1]. Yamada K et al. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov;12(11):896-898.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C21H24F3N7O2
Molecular Weight 463.456
Exact Mass 463.194366
LogP 2.01
Index of Refraction 1.631
Storage condition -20℃

 Synonyms

N-(2-Methyl-2-propanyl)-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl}-4-piperidinyl)-1H-imidazole-5-carboxamide
1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-
WNK463
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