MZP-55
Modify Date: 2024-01-10 16:15:13
MZP-55 structure
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Common Name | MZP-55 | ||
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| CAS Number | 2010159-48-3 | Molecular Weight | 1080.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C57H70ClN7O10S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MZP-55MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. |
| Name | MZP-55 |
|---|
| Description | MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. |
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| Related Catalog | |
| Target |
Kd: 8 nM (Brd4BD2)[1] |
| In Vitro | MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. MZP-55 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively[1]. |
| Cell Assay | MV4;11 or HL60 cells are incubated with MZP-55 at the desired concentration for 48 h on a clear-bottom 384-well plate. Cells are kept in RPMI medium supplemented with 10% FBS, l-glutamine, penicillin, and streptomycin. Initial cell density is 3 × 105 per mL. Cells are treated with various concentrations of MZP-55 or 0.05% DMSO. After treatment, cell viability is measured with cell viability assay kit. Signal is recorded. Data are analyzed with Graphpad Prism software to obtain EC50 values of each MZP-55[1]. |
| References |
| Molecular Formula | C57H70ClN7O10S |
|---|---|
| Molecular Weight | 1080.72 |
| Storage condition | 2-8℃ |