BK-1361(cyclo(RLsKDK))
Modify Date: 2025-08-21 19:03:34
BK-1361(cyclo(RLsKDK)) structure
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Common Name | BK-1361(cyclo(RLsKDK)) | ||
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| CAS Number | 1975145-82-4 | Molecular Weight | 727.865 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H57N11O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BK-1361(cyclo(RLsKDK))BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC. |
| Name | BK-1361 |
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| Description | BK-1361(BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM; displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM; inhibit shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology; decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC. |
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| References | References 1. Schlomann U, et al. Nat Commun. 2015 Jan 28;6:6175. 2. Chen J, et al. Sci Rep. 2016 Jul 26;6:30451. 3. Yim V, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4032-4037. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C31H57N11O9 |
|---|---|
| Molecular Weight | 727.865 |