N-Boc-L-trans-4,5-methanoproline

Modify Date: 2024-01-12 18:02:59

N-Boc-L-trans-4,5-methanoproline Structure
N-Boc-L-trans-4,5-methanoproline structure
Common Name N-Boc-L-trans-4,5-methanoproline
CAS Number 197142-34-0 Molecular Weight 227.257
Density 1.3±0.1 g/cm3 Boiling Point 355.9±25.0 °C at 760 mmHg
Molecular Formula C11H17NO4 Melting Point N/A
MSDS N/A Flash Point 169.0±23.2 °C

 Names

Name (1R,3S,5R)-2-[(2-methylpropan-2-yl)oxycarbonyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 355.9±25.0 °C at 760 mmHg
Molecular Formula C11H17NO4
Molecular Weight 227.257
Flash Point 169.0±23.2 °C
Exact Mass 227.115753
PSA 66.84000
LogP 0.41
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.537

 Synthetic Route

~75%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

~76%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ; Location in patent: Page/Page column 179-180 ;

~60%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ; Location in patent: Page/Page column 178-179 ;

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: Hanessian, Stephen; Reinhold, Ulrich; Gentile, Gabriella Angewandte Chemie (International Edition in English), 1997 , vol. 36, # 17 p. 1881 - 1884

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; THIBEAULT, Carl; EDWARDS, Paul, J.; KUHN, Cyrille; MOREAU, BenoIt; POIRIER, Maude; SURPRENANT, Simon Patent: WO2012/48421 A1, 2012 ;

~%

N-Boc-L-trans-4,5-methanoproline Structure

N-Boc-L-trans-4...

CAS#:197142-34-0

Literature: BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen Patent: WO2011/59850 A1, 2011 ;

 Synonyms

(1R,3S,5R)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
N-Boc-L-trans-4,5-methanoproline
(1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
(1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-tert-butyl ester
2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, (1R,3S,5R)-
(1R,3S,5R)-2-tert-butoxycarbonyl-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
(4R,5R)-metano-N-Boc-L-proline