LONAFARNIB

Modify Date: 2025-09-12 05:44:15

LONAFARNIB structure	Common Name	LONAFARNIB
	CAS Number	193275-86-4	Molecular Weight	638.822
	Density	1.5±0.1 g/cm3	Boiling Point	710.4±70.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₁Br₂ClN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	383.5±35.7 °C

Use of LONAFARNIB

(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].

Name	4-{2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl}-1-piperidinecarboxamide
Synonym	More Synonyms

Description	(Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
References	[1]. Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56.

Density	1.5±0.1 g/cm3
Boiling Point	710.4±70.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₁Br₂ClN₄O₂
Molecular Weight	638.822
Flash Point	383.5±35.7 °C
Exact Mass	636.050232
LogP	5.03
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.630
InChIKey	DHMTURDWPRKSOA-UHFFFAOYSA-N
SMILES	NC(=O)N1CCC(CC(=O)N2CCC(C3c4ncc(Br)cc4CCc4cc(Cl)cc(Br)c43)CC2)CC1

1-Piperidinecarboxamide, 4-[2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-

4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide

4-{2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl}-1-piperidinecarboxamide

MFCD06795138

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China
Product Name: Palmitic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LONAFARNIB
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Purity: 98.0%
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Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.