ximelagatran structure
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Common Name | ximelagatran | ||
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CAS Number | 192939-46-1 | Molecular Weight | 473.565 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C24H35N5O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of ximelagatranXimelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcokinetics and pharmacodynamics[1][2]. |
Name | ximelagatran |
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Synonym | More Synonyms |
Description | Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcokinetics and pharmacodynamics[1][2]. |
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Related Catalog | |
In Vitro | Ximelagatran is an orally administered direct thrombin inhibitor under development as an anticoagulant agent for prophylaxis against and treatment of thromboembolism. Ximelagatran is rapidly absorbed and quickly converted into its active form Melagatran, a reversible, active-site inhibitor of both free and clot-bound thrombin that has stable and reproducible pharmacokinetic properties. Initial studies have shown Ximelagatran to have good efficacy and safety in the prevention of venous thromboembolism after total knee or total hip replacement[3]. |
References |
Density | 1.4±0.1 g/cm3 |
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Molecular Formula | C24H35N5O5 |
Molecular Weight | 473.565 |
Exact Mass | 473.263824 |
PSA | 143.85000 |
LogP | 2.08 |
Index of Refraction | 1.635 |
ximelagatran |
ximelagatra |
Ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N-hydroxycarbamimidoyl)benzyl]carbamoyl}-1-azetidinyl]-2-oxoethyl}glycinate |
Exanta |
H-376/95 |
H 376-95 |
[14C]-Ximelagatran |
Ethyl (((1R)-1-cyclohexyl-2-((2S)-2-((4-(hydroxycarbamimidoyl)benzyl)carbamoyl)azetidin-1-yl-2-oxoethyl)amino)acetate |
H 376/95 |
[3H]-Ximelagatran |
Ximelagatran (JAN/USAN/INN) |
Exanta (TN) |
Exarta |
Ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate |
Glycine, N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]-, ethyl ester |
Ximelagatran [USAN:INN] |
ethyl 2-[[(1R)-1-cyclohexyl-2-[(2S)-2-[[4-[(Z)-N'-hydroxycarbamimidoyl]phenyl]methylcarbamoyl]azetidin-1-yl]-2-oxoethyl]amino]acetate |