PQR-530
Modify Date: 2025-09-11 15:51:00
PQR-530 structure
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Common Name | PQR-530 | ||
|---|---|---|---|---|
| CAS Number | 1927857-61-1 | Molecular Weight | 407.42 | |
| Density | 1.338±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H23F2N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PQR-530PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. |
| Name | PQR530 |
|---|---|
| Synonym | More Synonyms |
| Description | PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. |
|---|---|
| Related Catalog | |
| Target |
PI3K mTORC1 mTORC2 |
| In Vitro | PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. PQR-530 inhibits all PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM in A2058 melanoma cells. PQR-530 shows inhibitory activity against the growth of 44 cancer cell lines with mean GI50 of 426 nM[1]. |
| References |
| Density | 1.338±0.06 g/cm3 |
|---|---|
| Molecular Formula | C18H23F2N7O2 |
| Molecular Weight | 407.42 |
| InChIKey | SYKBZXMKAPICSO-NSHDSACASA-N |
| SMILES | CC1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2CCOCC2)n1 |
| Water Solubility | Practically insoluble (0.057 g/L) (25 ºC) |
| CPD1536 |
| PQR-530 |
| 4-(Difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-pyridinamine |