Bepotastine Besilate

Modify Date: 2025-08-26 17:21:04

Bepotastine Besilate Structure
Bepotastine Besilate structure
 Common Name Bepotastine Besilate
CAS Number 190786-44-8 Molecular Weight 547.063
Density N/A Boiling Point 546.8ºC at 760 mmHg
Molecular Formula C27H31ClN2O6S Melting Point 161-163°
MSDS N/A Flash Point 284.5ºC

 Use of Bepotastine Besilate


Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist. IC50 value:Target: Histamine H1 receptorBepotastine Beslilate (Bepreve) also suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).Bepotastine Beslilate (Bepreve) is useful for allergic conjunctivitis.

 Names

Name bepotastine besylate
Synonym More Synonyms

 Bepotastine Besilate Biological Activity

Description Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist. IC50 value:Target: Histamine H1 receptorBepotastine Beslilate (Bepreve) also suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).Bepotastine Beslilate (Bepreve) is useful for allergic conjunctivitis.
Related Catalog
References

[1]. Cho KH, Choi HG.Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs.Drug Dev Ind Pharm. 2012 Sep 10.

[2]. Meier EJ, Torkildsen GL, Gow JA, McNamara TR, Gomes PJ, Williams JI; for the Bepotastine Besilate Ophthalmic Solutions Study Group.Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular itching associated with allergic con

[3]. Kawakami T, Kimura S, Haga T, Doi R, Kyoya M, Nakagawa K, Soma Y.Health-related quality of life assessed by the effect of bepotastine besilate in patients with pruritus: importance of emotions score in atopic dermatitis.J Dermatol. 2012 Jun;39(6):527-30.

[4]. Williams JI, Kennedy KS, Gow JA, Torkildsen GL, Abelson MB, Gomes PJ, McNamara TR; Bepotastine Besilate Ophthalmic Solutions Study Group.Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allergic c

[5]. Kida, Tetsuo; Fujii, Atsuko; Sakai, Osamu; Iemura, Masahito; Atsumi, Ikuyo; Wada, Tomoyuki; Sakaki, Hideyuki. Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in i

 Chemical & Physical Properties

Boiling Point 546.8ºC at 760 mmHg
Melting Point 161-163°
Molecular Formula C27H31ClN2O6S
Molecular Weight 547.063
Flash Point 284.5ºC
Exact Mass 546.159119
PSA 125.41000
LogP 6.12220
Vapour Pressure 8.63E-13mmHg at 25°C
InChIKey UDGHXQPQKQPSBB-BOXHHOBZSA-N
SMILES O=C(O)CCCN1CCC(OC(c2ccc(Cl)cc2)c2ccccn2)CC1.O=S(=O)(O)c1ccccc1

 Safety Information

Hazard Codes Xi

 Synonyms

Bepotastine benzenesulfonate salt
UNII:6W18MO1QR3
Bepotastine Besilate
benzenesulfonic acid,4-[4-[(S)-(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
4-{4-[(S)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate
4-{4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl}butanoic acid benzenesulfonate (1:1)
Talion
Bepotastine besylate
UNII-6W18MO1QR3
TAU-284
Bepotastine benzenesulfonate
Betotastine besilate
1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1)
Bepotastine (Beslilate)
Bepreve
4-{4-[(S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate (1:1)
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