JTV-519 fumarate
Modify Date: 2025-11-02 13:19:27
JTV-519 fumarate structure
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Common Name | JTV-519 fumarate | ||
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| CAS Number | 1883549-36-7 | Molecular Weight | 540.675 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H36N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JTV-519 fumarateJTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively). Heart Arrhythmia Phase 2 Discontinued |
| Name | JTV-519 fumarate |
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| Description | JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9 uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca(2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively). Heart Arrhythmia Phase 2 Discontinued |
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| References | References 1. Darcy YL, et al. Mol Pharmacol. 2016 Aug;90(2):106-15. 2. Inagaki K, et al. Circulation. 2000 Feb 22;101(7):797-804. 3. Ito K, et al. Br J Pharmacol. 2000 Jun;130(4):767-76. 4. Nakaya H, et al. Br J Pharmacol. 2000 Dec;131(7):1363-72. View Related Products by Target Calcium Channel Heart Arrhythmia |
| Molecular Formula | C29H36N2O6S |
|---|---|
| Molecular Weight | 540.675 |
| InChIKey | ISLOBKLDZGDFTB-WLHGVMLRSA-N |
| SMILES | COc1ccc2c(c1)CN(C(=O)CCN1CCC(Cc3ccccc3)CC1)CCS2.O=C(O)C=CC(=O)O |