HOPan

Modify Date: 2024-01-03 10:45:28

HOPan Structure
HOPan structure
Common Name HOPan
CAS Number 18679-90-8 Molecular Weight 233.26
Density 1.23g/cm3 Boiling Point 556ºC at 760mmHg
Molecular Formula C10H19NO5 Melting Point N/A
MSDS N/A Flash Point 290.1ºC

 Use of HOPan


HoPan inhibits phosphopantotenoylcysteine synthetase activity.

 Names

Name 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid
Synonym More Synonyms

 HOPan Biological Activity

Description HoPan inhibits phosphopantotenoylcysteine synthetase activity.
Related Catalog
References

[1]. Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 556ºC at 760mmHg
Molecular Formula C10H19NO5
Molecular Weight 233.26
Flash Point 290.1ºC
Exact Mass 233.12600
PSA 106.86000
Vapour Pressure 1.11E-14mmHg at 25°C
Index of Refraction 1.508

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ES9570000
CHEMICAL NAME :
Butyric acid, 4-(2,4-dihydroxy-3,3-dimethylbutyramido)-, D-(+)-
CAS REGISTRY NUMBER :
18679-90-8
LAST UPDATED :
198511
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H19-N-O5
MOLECULAR WEIGHT :
233.30
WISWESSER LINE NOTATION :
QV3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,546,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

 Safety Information

HS Code 2924199090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

hopantenic acid
HOPA
Homopantothenic acid
4-D-pantoylamino-butyric acid
D-Homopantothenic acid
Hopantenic
4-D-Pantoylamino-buttersaeure
HOPan