Iruplinalkib

Modify Date: 2025-08-25 12:10:41

Iruplinalkib Structure
Iruplinalkib structure
Common Name Iruplinalkib
CAS Number 1854943-32-0 Molecular Weight 569.08
Density N/A Boiling Point N/A
Molecular Formula C29H38ClN6O2P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Iruplinalkib


Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement[1].

 Names

Name Iruplinalkib

 Iruplinalkib Biological Activity

Description Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement[1].
Related Catalog
Target

ALK and ROS1[1]

References

[1]. Shi Y, et al. Safety and activity of WX-0593 (Iruplinalkib) in patients with ALK- or ROS1-rearranged advanced non-small cell lung cancer: a phase 1 dose-escalation and dose-expansion trial. Signal Transduct Target Ther. 2022;7(1):25.

 Chemical & Physical Properties

Molecular Formula C29H38ClN6O2P
Molecular Weight 569.08
InChIKey ZPCCNHQDFZCULN-UHFFFAOYSA-N
SMILES COc1cc(N2CCC3(CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1
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