PEN-221

Modify Date: 2025-08-25 18:49:24

Use of PEN-221

PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM.

Name	PEN-221

Description	PEN-221 is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
Target	IC50: 10 nM (SSTR2)[1]
References	[1]. White BH, et al. Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo. J Med Chem. 2019 Mar 14;62(5):2708-2719.

Molecular Formula	C₈₃H₁₀₉ClN₁₄O₂₀S₄
Molecular Weight	1786.55