PD166326
Modify Date: 2025-08-26 17:45:15
PD166326 structure
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Common Name | PD166326 | ||
|---|---|---|---|---|
| CAS Number | 185039-91-2 | Molecular Weight | 427.283 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 646.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H16Cl2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 344.7±34.3 °C | |
Use of PD166326PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, with IC50s of 6 nM and 8 nM for Src and Abl, respectively. PD166326 exhibits antileukemic activity[1][2]. |
| Name | pd 166326 |
|---|---|
| Synonym | More Synonyms |
| Description | PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, with IC50s of 6 nM and 8 nM for Src and Abl, respectively. PD166326 exhibits antileukemic activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 6 nM (Src), 8 nM (Abl)[1] |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 646.3±65.0 °C at 760 mmHg |
| Molecular Formula | C21H16Cl2N4O2 |
| Molecular Weight | 427.283 |
| Flash Point | 344.7±34.3 °C |
| Exact Mass | 426.065033 |
| PSA | 80.04000 |
| LogP | 3.04 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.706 |
| InChIKey | ZIQFYVPVJZEOFS-UHFFFAOYSA-N |
| SMILES | Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(CO)c3)nc21 |
| Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl- |
| 6-(2,6-Dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one |