Cofrogliptin (HSK7653)(compound 2)

Modify Date: 2024-01-03 01:57:32

Cofrogliptin (HSK7653)(compound 2) structure	Common Name	Cofrogliptin (HSK7653)(compound 2)
	CAS Number	1844874-26-5	Molecular Weight	466.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₉F₅N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cofrogliptin (HSK7653)(compound 2)

Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1].

Name	D-arabino-Hexitol, 5-amino-2,6-anhydro-1,3,4,5-tetradeoxy-6-C-(2,5-difluorophenyl)-3-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]-1,1,1-trifluoro-, (6R)-
Synonym	More Synonyms

Description	Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) [1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	IC50: 4.18 nM (DPP-4) [2]
In Vitro	Cofrogliptin (HSK7653) (compound 2) has the DPP-4 inhibitory activity with an IC50 value of 4.18 nM[2].
References	[1]. International Nonproprietary Names for Pharmaceutical Substances (INN) [2]. Chen Zhang, et al. Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. J Med Chem. 2020 Jul 9;63(13):7108-7126.

Molecular Formula	C₁₈H₁₉F₅N₄O₃S
Molecular Weight	466.43
InChIKey	GUBOXFWNNXSQNH-SVGFKBNWSA-N
SMILES	CS(=O)(=O)n1cc2c(n1)CN(C1CC(N)C(c3cc(F)ccc3F)OC1C(F)(F)F)C2

Cofrogliptin (HSK7653) (compound 2)

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Cofrogliptin (HSK7653)(compound 2)

Use of Cofrogliptin (HSK7653)(compound 2)

Names

Cofrogliptin (HSK7653)(compound 2) Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.