AD 2900
Modify Date: 2024-07-22 10:02:52
AD 2900 structure
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Common Name | AD 2900 | ||
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| CAS Number | 18360-29-7 | Molecular Weight | 345.568 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H43NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AD 2900AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively; shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs; accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes, shows significant effects on the localization of T-cell subpopulations in mice. |
| Name | AD 2900 |
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| Description | AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively; shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs; accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes, shows significant effects on the localization of T-cell subpopulations in mice. |
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| References | References 1. Song J, et al. Oncotarget. 2017 Jun 27;8(32):53563-53580. 2. Dagan A, et al. Biochim Biophys Acta. 2003 Sep 22;1633(3):161-9. View Related Products by Target Lysophospholipid Receptor |
| Molecular Formula | C20H43NO3 |
|---|---|
| Molecular Weight | 345.568 |