SMAP-2

Modify Date: 2025-08-25 15:41:05

SMAP-2 Structure
SMAP-2 structure
 Common Name SMAP-2
CAS Number 1809068-70-9 Molecular Weight 532.57
Density N/A Boiling Point N/A
Molecular Formula C27H27F3N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SMAP-2


SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

 Names

Name SMAP-2

 SMAP-2 Biological Activity

Description SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].
Related Catalog
Target

PP2A[1]

References

[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.

 Chemical & Physical Properties

Molecular Formula C27H27F3N2O4S
Molecular Weight 532.57
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Chemsrc provides SMAP-2(CAS#:1809068-70-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SMAP-2 are included as well.>> amp version: SMAP-2

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