Aminooxy-PEG4-acid

Modify Date: 2024-01-02 23:10:25

Aminooxy-PEG4-acid Structure
Aminooxy-PEG4-acid structure
Common Name Aminooxy-PEG4-acid
CAS Number 1807537-38-7 Molecular Weight 281.303
Density 1.2±0.1 g/cm3 Boiling Point 448.6±45.0 °C at 760 mmHg
Molecular Formula C11H23NO7 Melting Point N/A
MSDS N/A Flash Point 225.1±28.7 °C

 Use of Aminooxy-PEG4-acid


Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Aminoxy-PEG4-acid
Synonym More Synonyms

 Aminooxy-PEG4-acid Biological Activity

Description Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 448.6±45.0 °C at 760 mmHg
Molecular Formula C11H23NO7
Molecular Weight 281.303
Flash Point 225.1±28.7 °C
Exact Mass 281.147461
LogP -1.49
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.468

 Synonyms

3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-(aminooxy)-
MFCD28015778
1-(Aminooxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
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