N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide

Modify Date: 2024-01-02 15:21:33

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide structure	Common Name	N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide
	CAS Number	180384-56-9	Molecular Weight	577.57200
	Density	1.485g/cm3	Boiling Point	754.5ºC at 760 mmHg
	Molecular Formula	C₂₅H₂₃N₉O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	410.1ºC

Use of N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].

Name	N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
Synonym	More Synonyms

Description	Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
In Vitro	Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5].
In Vivo	Clazosentan (10 μM, 0.05 mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats[2]. Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice[4]. Animal Model: Rats[2] Dosage: 10 μM, 0.05 mL/kg Administration: Intracisternal injection Result: Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.

Density	1.485g/cm3
Boiling Point	754.5ºC at 760 mmHg
Molecular Formula	C₂₅H₂₃N₉O₆S
Molecular Weight	577.57200
Flash Point	410.1ºC
Exact Mass	577.14900
PSA	208.49000
LogP	3.54870
Vapour Pressure	6.34E-24mmHg at 25°C
Index of Refraction	1.649

UNII-3DRR0X4728

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N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide

Use of N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide

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